abstract：:Purpose: To provide insights into the energy requirements as well as the physiological adaptations of an experienced 50-year-old ultra-marathon male athlete during the world's most challenging mountain ultra-marathon (MUM). Methods: The international race supporting the study was the Tor des Geants®, characterized by ...

journal_title：Frontiers in physiology

authors： Savoldelli A,Fornasiero A,Trabucchi P,Limonta E,La Torre A,Degache F,Pellegrini B,Millet GP,Vernillo G,Schena F

更新日期：2017-12-05 00:00:00

abstract：:Chronic pressure overload can result in ventricular hypertrophy and eventually diastolic dysfunction. In normal myocardium, the time from peak tension to 50% relaxation of isolated cardiac myocardium is not directly determined by the time for calcium decline. This study aims to determine whether the time for calcium d...

journal_title：Frontiers in physiology

authors： Monasky MM,Torres CAA,Janssen PML

更新日期：2017-12-04 00:00:00

abstract：:Plant-insect interactions constitute a complex of system, whereby plants synthesize toxic compounds as the main defense strategy to combat herbivore assault, and insects deploy detoxification systems to cope with toxic plant compounds. Cytochrom P450s are among the main detoxification enzymes employed by insects to co...

journal_title：Frontiers in physiology

authors： Peng L,Zhao Y,Wang H,Song C,Shangguan X,Ma Y,Zhu L,He G

更新日期：2017-11-30 00:00:00

abstract：:Aphidius gifuensis is one of the most important aphid natural enemies and has been successfully used to control Myzys persicae and other aphid species. High temperature in summer is one of the key barriers for the application of A. gifuensis in the field and greenhouse. In this work, we investigated the biological per...

journal_title：Frontiers in physiology

authors： Kang ZW,Liu FH,Liu X,Yu WB,Tan XL,Zhang SZ,Tian HG,Liu TX

更新日期：2017-11-28 00:00:00

abstract：:Invasive coronary revascularization has been shown to improve prognoses in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but the optimal timing of intervention remains unclear. This meta-analysis is to evaluate the outcomes in immediate (<2 h), early (<24 h), and delayed invasive group an...

journal_title：Frontiers in physiology

authors： Li Y,Zhang Z,Xiong X,Cho WC,Hu D,Gao Y,Shang H,Xing Y

更新日期：2017-11-27 00:00:00

abstract：:Characterization of flow properties in cerebral arteries with 1.5 and 3 Tesla MRI is usually limited to large cerebral arteries and difficult to evaluate in the small perforating arteries due to insufficient spatial resolution. In this study, we assessed the feasibility to measure blood flow waveforms in the small len...

journal_title：Frontiers in physiology

authors： Schnerr RS,Jansen JFA,Uludag K,Hofman PAM,Wildberger JE,van Oostenbrugge RJ,Backes WH

更新日期：2017-11-24 00:00:00

abstract：:The hippocampus is known as a neuronal structure involved in learning, memory and spatial navigation using multi-sensory cues. However, the basic features of its response to acoustic stimuli without any behavioral tasks (conditioning) remains poorly studied. Here, we investigated the CA3 response to auditory stimuli u...

journal_title：Frontiers in physiology

authors： Wang N,Gan X,Liu Y,Xiao Z

更新日期：2017-11-21 00:00:00

abstract：:One-third of the world's population has been infected with Mycobacterium tuberculosis (M. tuberculosis), a primary pathogen of the mammalian respiratory system, while about 10% of latent infections progress to active tuberculosis (TB), indicating that host and environmental factors may determine the outcomes such as i...

journal_title：Frontiers in physiology

authors： Luo M,Liu Y,Wu P,Luo DX,Sun Q,Zheng H,Hu R,Pandol SJ,Li QF,Han YP,Zeng Y

更新日期：2017-11-17 00:00:00

abstract：:A number of years ago we reported that ventral Lateral Neurons (LNvs), which are essential in the control of rest-activity cycles in Drosophila, undergo circadian remodeling of their axonal projections. This structural plasticity gives rise to changes in the degree of connectivity, which could provide a means of trans...

journal_title：Frontiers in physiology

authors： Herrero A,Duhart JM,Ceriani MF

更新日期：2017-11-14 00:00:00

abstract：:Aim: Acute ingestion of alcohol is often accompanied by cardiovascular dysregulation, malaise and even syncope. The full hemodynamic and cutaneous responses to the combination of alcohol and sugar (i.e., alcopops), a common combination in young people, and the mechanisms for the propensity to orthostatic intolerance a...

journal_title：Frontiers in physiology

authors： Maufrais C,Charriere N,Montani JP

更新日期：2017-11-10 00:00:00

abstract：:Mitochondria are the major source of superoxide radicals and superoxide overproduction contributes to cardiovascular diseases and metabolic disorders. Endothelial dysfunction and diminished nitric oxide levels are early steps in the development of these pathological conditions. It is known that physiological productio...

journal_title：Frontiers in physiology

authors： Dikalov SI,Mayorov VI,Panov AV

更新日期：2017-11-07 00:00:00

abstract：:Background: Constant blood flow despite changes in blood pressure, a phenomenon called autoregulation, has been demonstrated for various organ systems. We hypothesized that by changing hydrostatic pressures in peripheral arteries, we can establish these limits of autoregulation in peripheral arteries based on local pu...

journal_title：Frontiers in physiology

authors： Tripathi A,Obata Y,Ruzankin P,Askaryar N,Berkowitz DE,Steppan J,Barodka V

更新日期：2017-11-02 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Maximum aerobic power ([Formula: see text]) as an indicator of body fitness is today a very well-known concept not just for athletes but also for the layman. Unfortunately, the accurate measurement of that variable has remained a complex and exhaustive laboratory procedure, which makes it inaccessible to many active p...

journal_title：Frontiers in physiology

authors： Storniolo JL,Pavei G,Minetti AE

更新日期：2017-11-01 00:00:00

abstract：:The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier. High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it difficult to elucidate its regulation....

journal_title：Frontiers in physiology

authors： Fung KY,Wang C,Nyegaard S,Heit B,Fairn GD,Lee WL

更新日期：2017-10-30 00:00:00

abstract：:Infants born premature are at increased risk for development of bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), and ultimately right ventricular (RV) dysfunction, which together carry a high risk of neonatal mortality. However, the role alveolar simplification and abnormal pulmonary microvascular develo...

journal_title：Frontiers in physiology

authors： Patel JR,Barton GP,Braun RK,Goss KN,Haraldsdottir K,Hopp A,Diffee G,Hacker TA,Moss RL,Eldridge MW

更新日期：2017-10-25 00:00:00

abstract：:Background: The severity of wildland fires is increasing due to continually hotter and drier summers. Firefighters are required to make life altering decisions on the fireground, which requires analytical thinking, problem solving, and situational awareness. This study aimed to determine the effects of very hot (45°C;...

journal_title：Frontiers in physiology

authors： Williams-Bell FM,Aisbett B,Murphy BA,Larsen B

更新日期：2017-10-24 00:00:00

abstract：:Exercise and physical labor in extreme environmental conditions causes transient decreases in immune cell and cytokine concentrations, likely increasing the susceptibility to opportunistic infection. Baker's yeast beta glucan (BYBG) has been previously demonstrated to be an effective countermeasure in athletes, but it...

journal_title：Frontiers in physiology

authors： McFarlin BK,Venable AS,Carpenter KC,Henning AL,Ogenstad S

更新日期：2017-10-20 00:00:00

abstract：:The extracellular tooth enamel matrix is a unique, protein-rich environment that provides the structural basis for the growth of long and parallel oriented enamel crystals. Here we have conducted a series of in vivo and in vitro studies to characterize the changes in matrix shape and organization that take place durin...

journal_title：Frontiers in physiology

authors： Pandya M,Lin T,Li L,Allen MJ,Jin T,Luan X,Diekwisch TGH

更新日期：2017-10-17 00:00:00

abstract：:The complex interactions that give rise to heart rate variability (HRV) involve coupled physiological oscillators operating over a wide range of different frequencies and length-scales. Based on the premise that interactions are key to the functioning of complex systems, the time-dependent deterministic coupling param...

journal_title：Frontiers in physiology

authors： Ticcinelli V,Stankovski T,Iatsenko D,Bernjak A,Bradbury AE,Gallagher AR,Clarkson PBM,McClintock PVE,Stefanovska A

更新日期：2017-10-13 00:00:00

abstract：:Objective: Neuromuscular injury prevention programs (IPP) can reduce injury rate by about 40% in youth sport. Multimodal IPP include, for instance, balance, strength, power, and agility exercises. Our systematic review and meta-analysis aimed to evaluate the effects of multimodal IPP on neuromuscular performance in yo...

journal_title：Frontiers in physiology

authors： Faude O,Rössler R,Petushek EJ,Roth R,Zahner L,Donath L

更新日期：2017-10-12 00:00:00

abstract：:Giant clams live in symbiosis with extracellular zooxanthellae and display high rates of growth and shell formation (calcification) in light. Light-enhanced calcification requires an increase in the supply of Ca2+ to, and simultaneously an augmented removal of H+ from, the extrapallial fluid where shell formation occu...

journal_title：Frontiers in physiology

authors： Ip YK,Hiong KC,Goh EJK,Boo MV,Choo CYL,Ching B,Wong WP,Chew SF

更新日期：2017-10-10 00:00:00

abstract：:Exercise and exogenous heat each stimulate multiple adaptations, but their roles are not well delineated, and that of the related stressor, dehydration, is largely unknown. While severe and prolonged hypohydration potentially "silences" the long-term heat acclimated phenotype, mild and transient dehydration may enhanc...

journal_title：Frontiers in physiology

authors： Akerman AP,Lucas SJE,Katare R,Cotter JD

更新日期：2017-10-09 00:00:00

abstract：:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were develope...

journal_title：Frontiers in physiology

authors： de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BA

更新日期：2017-10-04 00:00:00

abstract：:Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease ge...

journal_title：Frontiers in physiology

authors： Zheng T,Ni Y,Li J,Chow BKC,Panagiotou G

更新日期：2017-09-28 00:00:00

abstract：:Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed continuously in intracellular and extracellular locations of all tissues. Extra...

journal_title：Frontiers in physiology

authors： Arin RM,Gorostidi A,Navarro-Imaz H,Rueda Y,Fresnedo O,Ochoa B

更新日期：2017-09-22 00:00:00

abstract：:Hypoxic environments at high altitude have significant effects on kidney injury. Following injury, renal primary cilia display length alterations. Primary cilia are mechanosensory organelles that regulate tubular architecture. The effect of hypoxia on cilia length is still controversial in cultured cells, and no corre...

journal_title：Frontiers in physiology

authors： Shamloo K,Chen J,Sardar J,Sherpa RT,Pala R,Atkinson KF,Pearce WJ,Zhang L,Nauli SM

更新日期：2017-09-20 00:00:00

abstract：:The ability to sustain submaximal exercise is largely dependent on the oxidative capacity of mitochondria within skeletal muscle, and impairments in oxidative metabolism have been implicated in many neurologic and cardiovascular pathologies. Here we review studies which have demonstrated the utility of Near-infrared s...

journal_title：Frontiers in physiology

authors： Willingham TB,McCully KK

更新日期：2017-09-14 00:00:00

abstract：:Purpose: The mechanisms involved in the coordination of muscle activity are not completely known: to investigate adaptive changes in human motor cortex Transcranial magnetic stimulation (TMS) was often used. The sport models are frequently used to study how the training may affect the corticospinal system excitability...

journal_title：Frontiers in physiology

authors： Monda V,Valenzano A,Moscatelli F,Salerno M,Sessa F,Triggiani AI,Viggiano A,Capranica L,Marsala G,De Luca V,Cipolloni L,Ruberto M,Precenzano F,Carotenuto M,Zammit C,Gelzo M,Monda M,Cibelli G,Messina G,Messina A

更新日期：2017-09-12 00:00:00

abstract：:Aim: The hemodynamic response to mouse systemic anaphylaxis is characterized by an initial hypertension followed by sustained hypotension. However, the defense mechanisms of the sympathetic nervous system against this circulatory disturbance is not known. Here, we investigated the renal sympathetic nerve activity (RSN...

journal_title：Frontiers in physiology

authors： Zhang T,Tanida M,Uchida K,Suzuki Y,Yang W,Kuda Y,Kurata Y,Tominaga M,Shibamoto T

更新日期：2017-09-07 00:00:00

abstract：:For many hereditary disorders, although the underlying genetic mutation may be known, the molecular mechanism leading to hemolytic anemia is still unclear and needs further investigation. Previous studies revealed an increased intracellular Ca2+ in red blood cells (RBCs) from patients with sickle cell disease, thalass...

journal_title：Frontiers in physiology

authors： Hertz L,Huisjes R,Llaudet-Planas E,Petkova-Kirova P,Makhro A,Danielczok JG,Egee S,Del Mar Mañú-Pereira M,van Wijk R,Vives Corrons JL,Bogdanova A,Kaestner L

更新日期：2017-09-06 00:00:00

abstract：:Activation of autonomic neural pathways by chronic hypertensive stimuli plays a significant role in pathogenesis of hypertension. Here, we proposed that even a single acute hypertensive stimulus will activate neural and immune pathways that may be important in initiation of memory imprinting seen in chronic hypertensi...

journal_title：Frontiers in physiology

authors： Zubcevic J,Santisteban MM,Perez PD,Arocha R,Hiller H,Malphurs WL,Colon-Perez LM,Sharma RK,de Kloet A,Krause EG,Febo M,Raizada MK

更新日期：2017-08-31 00:00:00

abstract：:Swimming induced pulmonary edema (SIPE) is a complication that can occur during exercise with the possibility of misdiagnosis and can quickly become life threatening; however, medical literature infrequently describes SIPE. Therefore, the aim of this review was to analyse all individual cases diagnosed with SIPE as re...

journal_title：Frontiers in physiology

authors： Grünig H,Nikolaidis PT,Moon RE,Knechtle B

更新日期：2017-08-31 00:00:00

abstract：:Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability...

journal_title：Frontiers in physiology

authors： Ihlen EAF,van Schooten KS,Bruijn SM,Pijnappels M,van Dieën JH

更新日期：2017-08-29 00:00:00

abstract：:Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial and the mechanisms underlying these effects remain largely unknown. This study aimed to investigate the potential relationship between the regulation of obesity and glucose homeostasis by dietary capsaicin and the alteratio...

journal_title：Frontiers in physiology

authors： Song JX,Ren H,Gao YF,Lee CY,Li SF,Zhang F,Li L,Chen H

更新日期：2017-08-25 00:00:00

abstract：:There are two primary components that produce pulmonary arterial hypertension (PAH); aberrant structural changes (smooth muscle cell proliferation, smooth muscle cell hypertrophy, and the deposition of matrix proteins within the media of pulmonary arterial vessels), and excess vasoconstriction. However, in PAH, the ta...

journal_title：Frontiers in physiology

authors： Lyle MA,Davis JP,Brozovich FV

更新日期：2017-08-23 00:00:00

abstract：:Background: Chronic infection with HBV (CHB) or HCV (CHC) is the most common chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma in humans, their infections have distinct pathogenic processes, however, little is known about the difference of glycoprotein glycopatterns in serum between hepat...

journal_title：Frontiers in physiology

authors： Qin X,Guo Y,Du H,Zhong Y,Zhang J,Li X,Yu H,Zhang Z,Jia Z,Li Z

更新日期：2017-08-21 00:00:00

abstract：:Although motor output of the postural function clearly influences postural performance in young and older subjects, no relationship has been formally established between them. However, the relationship between lower-extremity muscle strength/power and postural performance is often pointed out, especially in older subj...

journal_title：Frontiers in physiology

authors： Paillard T

更新日期：2017-08-15 00:00:00

abstract：:[This corrects the article on p. 165 in vol. 7, PMID: 27242539.]. ...

journal_title：Frontiers in physiology

authors： Nielsen AL,Chen S,Fleischer SJ

更新日期：2017-08-11 00:00:00

abstract：:FXYD proteins are important regulators of Na+/K+-ATPase (NKA) activity in mammals. As an inhabitant of estuaries, the pufferfish (Tetraodon nigroviridis) responds to ambient salinity changes with efficient osmoregulation, including alterations in branchial, and renal NKA activities. Previous studies on teleostean FXYD...

journal_title：Frontiers in physiology

authors： Wang PJ,Yang WK,Lin CH,Hwang HH,Lee TH

更新日期：2017-08-08 00:00:00